Over the past two decades, elegant work from Dr. R. Shoemaker and his colleagues has demonstrated unequivocally that biotoxins such as mycotoxins are associated with a broad range of symptoms, including cognitive decline (summarized in ). These researchers and clinicians identified a constellation of symptoms, signs, genetic predisposition (HLA-DR/DQ haplotypes), and laboratory abnormalities characteristic of patients exposed to, and sensitive to, these biotoxins. The resulting syndrome has been designated chronic inflammatory response syndrome (CIRS).
Steroid injections are commonly used to treat rotator cuff tendinopathy, but controlled studies have demonstrated modest benefit, particularly in the long term. 34 Steroid injections should be reserved for patients who have discomfort that would limit them from engaging in rehabilitative exercises. Injections into the gluteal muscle versus guided injections into the subacromial bursa have demonstrated similar levels of pain relief. 35 Surgical options are available for patients with persistent symptoms, or for patients in whom function cannot be maintained.
Given the relative safety and superior effectiveness of honey plus coffee versus prednisolone, this study adds to a growing body of biomedical research indicating that natural substances, including spices, vitamins and foods, are often superior in efficacy to synthetic drugs while often maintaining far higher levels of safety relative to them.
[i] Mohammad Ali Raeessi, Jafar Aslani, Neda Raeessi, Homa Gharaie, Ali Akbar Karimi Zarchi, Fereshteh Raeessi. Honey plus coffee versus systemic steroid in the treatment of persistent post-infectious cough: a randomised controlled trial.