Oxymetholone metabolites

Anadrol cycles are normally composed of Anadrol as a kickstarting compound for the first 4 – 6 weeks where it is supplementary to other injectable base compounds that are used for similar purposes, such as Testosterone Enanthate, Deca-Durabolin (Nandrolone Decanoate), Trenbolone Enanthate, etc. It can also be utilized in the middle of a cycle in order to push through any sticking points or plateaus in training progress. Additionally, some users throw it into the end of a cycle in order to boost the end of a cycle and act as a ‘finisher’ compound in a cycle, leaving the user to end off their cycle with some very impressive strength and size gains as they move into the PCT (Post Cycle Therapy) phase.

Oxymetholone for women: what a lady athlete should know about it.
In conclusion one can safely state that the negative effects on the system associated with the use of this hormone are rather drastic and that the use is therefore not recommended for beginners, women or people who have pre-existing afflictions. Nonetheless Anadrol remains a popular steroid among experienced users to kick-start a steroid cycle because of its magnificent increases in strength and size. Most people who have used oxymetholone with great success have no problem calling it the strongest and most reliable steroid available today. A somewhat surprising remark however, since Methandrostenolone can produce similar results with half or a third of the doses normally used with oxymetholone and with less side-effects. So personally I would recommend methandrostenolone over oxymethelone, as its clearly stronger, milligram fro milligram. Oxymetholone remains a strong and favorable compound however, despite its side-effects. Its effects may also be slightly more explosive than those of methandrostenolone and therefore people seeking strength may give it an edge over the former.

One of the biotransformation routes of oxymetholone (17β-hydroxy-2-hydroxymethylene-17α-methyl-5α-androstan-3-one) in man leads to the formation of 17β-hydroxy-17α-methyl-5α-androstan-3-one (mestanolone). To demonstrate that this latter steroid may be formed by decarboxylation of an intermediate metabolite of oxymetholone bearing a 2-carboxylic group, we studied the urinary excretion of oxymetholone acidic metabolites. Five new acidic metabolites are reported here for the first time, among which four are unusual seco steroids resulting from the oxidative cleavage of the A-ring. The most abundant compound is 17β-hydroxy-17α-methyl-2,3-seco-5α-androstane-2,3-dioic acid 1 , the cumulative excretion of which accounted for % of the dose. Three other seco diacids were produced in smaller amounts, namely 17β-hydroxy-17α-methyl-2,3-seco-5α-androstane-2,4-dicarboxylic acid 3 , 17β-hydroxy-17α-methyl-1,3-seco-5α-androstane-1,3-dioic acid 4 and 17β-hydroxy-17α-methyl-2,4-seco-5α-androstane-2,4-dioic acid 5 . The fifth acidic metabolite was identified as 3α, 17β-dihydroxy-17α-methyl-5α-androstane-2β-carboxylic acid 2 . The excretion in urine of these acidic metabolites suggests that the 2-hydroxymethylene group in oxymetholone is readily oxidized to yield the corresponding β-keto acid which can be (1) decarboxylated to form mestanolone; (2) reduced at C-3 to give compound 2 ; and (3) further oxidized to afford the unexpected seco diacids 1,3,4 and 5 . The identity of compounds 1 and 2 was ascertained by GC/MS and 1 H and 13 C-NMR analysis of reference compounds. The other metabolites were characterized by GC/MS analysis.

Oxymetholone metabolites

oxymetholone metabolites

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