This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about propylthiouracil. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using propylthiouracil.
Mirtazapine does not have serotonergic activity and does not cause serotonergic side effects or serotonin syndrome .   This is in accordance with the fact that it is not a serotonin reuptake inhibitor or MAOI, nor a serotonin receptor agonist .   There are no reports of serotonin syndrome in association with mirtazapine alone, and mirtazapine has not been found to cause serotonin syndrome in overdose.    However, there are a handful of case reports of serotonin syndrome occurring with mirtazapine in combination with serotonergic drugs like SSRIs, although such reports are unusual, very rare, and do not necessarily implicate mirtazapine as causative.       The addition of mirtazapine to an MAOI does not cause serotonin syndrome, and has been considered to be a safe combination.   Moreover, mirtazapine may actually be useful in the treatment of serotonin syndrome, with at least one publication finding it to be effective in resolving the syndrome.    This is in accordance with the fact that the 5-HT 2A receptor is the predominant serotonin receptor thought to be involved in the pathophysiology of serotonin syndrome (with the 5-HT 1A receptor seeming to be protective).   Mirtazapine is a potent 5-HT 2A receptor antagonist, and cyproheptadine , a drug that shares this property, mediates recovery from serotonin syndrome and is well-established clinically as an antidote against it.