Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder. 
Revised monographs: Delavirdine, Enfuvirtide, Tipranavir, Maraviroc, Didanosine, Stavudine, Saquinavir, Indinavir, Ritonavir, Nelfinavir, Eprosartan, Telmisartan, Eplerenone, Nebivolol, Guanfacine, Azilsartan, Sodium Nitroprusside, Methyldopa, Clonidine, Prazosin, Hydralazine, Isosorbide, Propranolol, Minoxidil, Nadolol, Metoprolol, Rauwolfia Alkaloids, Nitrates and Nitrites General Statement, Timolol, Atenolol, Pindolol, Labetalol, Acebutolol, Esmolol, Felodipine, Fosinopril, Quinapril, Lisinopril, Bisoprolol, Doxazosin, Terazosin, Betaxolol, Isradipine, Losartan, Moexipril, Trandolapril, Carvedilol, Perindopril, Tapentadol, Acetaminophen, Hydrocodone, Codeine, Oxycodone, Ibuprofen, Clonazepam, Pentazocine, Aspirin, Opiate Agonists General Statement, Tramadol, Amiloride, Triamterene, Chlorothiazide, Chlorthalidone, Metolazone, Methyclothiazide, Hydrochlorothiazide, Bendroflumethiazide, Spironolactone, Ethacrynic Acid, Furosemide, Bumetanide, Indapamide, Torsemide, Hydrocodone, Canagliflozin, Diazoxide, Dexamethasone, Hydrocortisone, Methylprednisolone, Metformin, Pioglitazone, Rosiglitazone, Antivenin (Latrodectus mactans) (Equine).
A 2005 paper suggested leuprorelin as a possible treatment for autism ,  the hypothetical method of action being the now defunct hypothesis that autism is caused by mercury , with the additional unfounded assumption that mercury binds irreversibly to testosterone and therefore leuprorelin can help cure autism by lowering the testosterone levels and thereby mercury levels.  However there is no scientifically valid or reliable research to show its effectiveness in treating autism.  This use has been termed the "Lupron protocol"  and Mark Geier , the proponent of the hypothesis, has frequently been barred from testifying in vaccine-autism related cases on the grounds of not being sufficiently expert in that particular issue    and has had his medical license revoked.  Medical experts have referred to Geier's claims as "junk science".