What may not be fully known by the average user is that the studies conducted on animals as well as humans have in fact demonstrated the negative effects that Clenbuterol may exhibit on cardiac tissue . A common question asked by individuals who use or are seeking to use Clenbuterol is that of what possible effect are there on the heart and related tissues and organs? The important distinction to note and remember here is the context and environment of the study in which Clenbuterol was administered to the test subjects. There have been numerous studies demonstrating Clenbuterol’s effect of cardiac tissue cell death in rats, but the context must be understood where the amounts of Clenbuterol administered to rats would come to the equivalent of massive overdoses for a human. One particular study had observed two male bodybuilders (ages 18 and 22 years) that were admitted to the Emergency Room suffering from palpitations, nausea, vomiting, chest pain, diaphoresis and tachycardia shortly after ingesting Clenbuterol. It was found that myocardial ischemia was the result of Clenbuterol use from these two bodybuilders  . Mycardial ischemia is a condition in which there is a local insufficiency of blood supply to the heart, which is a result of arterial vasoconstriction (caused by Clenbuterol). What exactly were the circumstances surrounding these two bodybuilders were remains unknown (whether or not they had knowingly or unknowingly overdosed, or perhaps reacted badly due to an unforeseen individual response).