LH: I think you’re right about needing some sort of predispositon. That said, most kidney disease is never biopsied, and renal dysfunction, especially in middle-aged or older people, is usually attributed to hypertension or other common disorders. The entity of secondary FSGS is a relatively new construct (last 20 years or so) and as a pathologist, I struggle every day to make it clear to nephrologists when I think a patient has FSGS that’s due to obesity or hypertension. The last thing patients need is treatment with prednisone, a corticosteroid, or other immunosuppressant, which are the mainstays of treatment for primary FSGS.
The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.