It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Post-cycle therapy is not difficult. In fact, if you want to continue enjoying your Anadrol results, it is necessary. You will need a drug called a Selective Estrogen Receptor Modulator, or SERM. While its main purpose involves binding to estrogen receptors in such a way that it blocks some of the actions of estrogen, it has the added benefit of stimulating the production of LH and FSH, or Luteinizing Hormone and Follicle Stimulating Hormone, respectively. These two hormones tell your testicles to produce testosterone, and this is important for maintaining your gains post-cycle.
Regardless of your Anadrol doses, where they may fall, no man should use this steroid for more than eight weeks. In fact, most men should not extend use past six weeks if they are going to protect their health. Use that extends past six weeks also appears to provide little benefit in terms of growth, meaning there’s really no point in extending use. Many men will find the bulk of the results occur within the first four weeks of use regardless of the Anadrol doses. This makes 4-6 weeks the perfect time frame for most men. Such a time frame of use will be the safest and will typically produce all the desired and obtainable results of this steroid.